Jacob Späth
Jacob Späth
Student / Programme Doctorate at D-CHAB
Research interest
Roles of adhesion molecules in immune cell migration through afferent lymphatics
Education & positions held
2024 - present
Ph.D. student with Prof. Dr. Cornelia Halin Winter, Institute of Pharmaceutical Sciences, Pharmaceutical Immunology, Swiss Federal Institute of Technology (ETH) Zurich, Switzerland
2023 - 2024
Visiting research student with Prof. Michel Dustin PhD, Kennedy Institute of Rheumatology, University of Oxford, United Kingdom
2022 - 2023
Master’s Thesis “GDF-15 fusion proteins as a treatment option for multiple sclerosis” with Prof. Dr. Wischhusen, Experimental Tumor Immunology, University of Würzburg School of Medicine, Germany
2021 - 2024
Master of Science (M.Sc.) in Biochemistry, University of Würzburg, Germany
2021 - 2023
Research assistant with Prof. Dr. Jörg Wischhusen, Experimental Tumor Immunology, University of Würzburg School of Medicine, Germany
2021
Bachelor’s thesis “Expression and characterisation of anti-VCAM-1 Fc GDF-15 fusion proteins” with Prof. Dr. Jörg Wischhusen, Experimental Tumor Immunology, University of Würzburg School of Medicine.
2018 - 2021
Bachelor of Science (B.Sc.) in Biochemistry, University of Würzburg, Germany
Publications
Haake M, Haack B, Schäfer T, Harter PN, Mattavelli G, Eiring P, Vashist N, Wedekink F, Genssler S, Fischer B, Dahlhoff J, Mokhtari F, Kuzkina A, Welters MJP, Benz TM, Sorger L, Thiemann V, Almanzar G, Selle M, Thein K, Späth J, Gonzalez MC, Reitinger C, Ipsen-Escobedo A, Wistuba-Hamprecht K, Eichler K, Filipski K, Zeiner PS, Beschorner R, Goedemans R, Gogolla FH, Hackl H, Rooswinkel RW, Thiem A, Roche PR, Joshi H, Pühringer D, Wöckel A, Diessner JE, Rüdiger M, Leo E, Cheng PF, Levesque MP, Goebeler M, Sauer M, Nimmerjahn F, Schuberth-Wagner C, von Felten S, Mittelbronn M, Mehling M, Beilhack A, van der Burg SH, Riedel A, Weide B, Dummer R, Wischhusen J. Tumor-derived GDF-15 blocks LFA-1 dependent T cell recruitment and suppresses responses to anti-PD-1 treatment. Nat Commun. 2023 Jul 20;14(1):4253. doi: 10.1038/s41467-023-39817-3.